Michiko Shimoda, PhD is an Assistant Professor in the Cancer Immunology, Inflammation and Tolerance Program at the GHSU Cancer Center. Dr. Shimoda earned her PhD (2002) from Tokyo University of Agriculture and Technology, Japan. She is an Assistant Professor in the Department of Pathology in the Medical College of Georgia at GHSU.
Dr. Shimoda studies the mechanisms of B cell and T cell lymphomagenesis in a spontaneous mouse lymphoma model using a variety of genomics and cell and molecular biology approaches. Her research focus is on the role of inflammatory response in lymphoma development.
Dr. Shimoda has been studying the role of B cell antigen presentation in the normal immune response and in autoimmune diseases using various mouse models. Using a conditional mouse model, in which B cells lack MHC-II expression, and in collaboration with Dr Pandelakis A. Koni (Cancer Center, GHSU), her group has shown that MHC-II expression is required for the differentiation of germinal center B cells and memory B cell formation, but not for the maintenance of established memory B cells. Using a B cell-specific CD40L transgenic mouse model in which B cells are exposed to excessive CD40/CD40L signaling, such as in human inflammatory diseases, her group has found that CD40L-expressing B cells have a capability to induce IL-10 expression in CD4 and CD8 T cells and regulate inflammatory responses. The latter finding may be useful in developing a therapy for T cell-mediated autoimmune diseases.
The Shimoda laboratory recently established a new mouse model of T cell acute leukemia/lymphoma (T-ALL). These mice generate CD4 CD8 double-positive T cell lymphoma precursor-like cells in the circulation under inflammatory conditions and later spontaneously develop T-ALL-like leukemia/lymphoma. Since this process resembles that of adult T-ALL, Dr Shimoda hopes these mice will be a useful model for understanding the mechanisms in which chronic inflammatory diseases drive T cell leukemia/lymphomagenesis. Her laboratory is currently investigating the molecular mechanisms of lymphomagenesis in this mouse model using various genomics and cell and molecular biology approaches.
- National Institue of Allergy and Infectious Disease: “Long-lived Plasma Cell Differentiation” 2007-2011, PI – Shimoda, M.
- National Institue of Arthritis and Musculoskeletal and Skin Diseases: “B Cell Antigen Presentation in Models of B Cell A” 2006-2011, PI – Shimoda, M.
Grants updated quarterly.